Projected Value of Protego-PD™ in NEC

The Efficacy and Value of Protego-PD™ in OA


  • Protego-PD™:
    • More predictable and consistent growth factor concentrations than amniotic fluid19
    • Prevents joint inflammation and cartilage breakdown;
      • Unique compared to: steroids, HA, PRP and amniotic fluid20-23
  • Preclinical in vivo results
  1. Data on file.  Plakous Therapeutics.  Winston-Salem, NC.
  2. Demesmin D, Beall D, Nalamachu S, Witherby J, Rana N.  Amniotic fluid as a homologue to synovial fluid: interim analysis of prospective, multi-center outcome observational cohort registry of amniotic fluid treatment for osteoarthritis of the knee.  Presented at American Academy of Pain Medicine Annual Meeting; March 2015; National Harbor, MD.
  3. Vine JB, Apiliprantis AO, Gomoll AH, Farr J.  Cryopreserved amniotic suspension for the treatment of knee osteoarthritis.  J Knee Surg. 2015;29(6):443-50.
  4. Tomblyn S, Ma X, Willey JS, Washburn S, Yammani R, Smith TL.  An acellular preparation of the post-delivery, term placenta prevents post-traumatic osteoarthritis following multi-ligament and meniscus injury in rats.  Presented at MHSRS Annual Meeting; August 2018; Orlando, FL.
  5. Ma X, Willey JS, Tomblyn S, Yammani R, Washburn S, Smith TL.  Effects of a post-delivery placenta disc extract on porcine hyaline cartilage matrix breakdown. Presented at ORS Annual Meeting; March 2018; New Orleans, LA.
  6. Ma X, Jinnah A, Tomblyn S, Willey JS, Washburn S, Yammani R, Feruson C, Smith T.  Effects of post-delivery placenta disc (HPH) on porcine hyaline cartilage matrix. Presented at AAOA Optimizing Clinical Use of Biologics in Orthopaedic Surgery; February 2018; Stanford, CA.

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